Coccoloba marginata Benth fruits: a rich source of bioactive compounds

Authors

  • João Vitor Souza Soares Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0003-4866-7210
  • Daniel Queiroz Rocha Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0009-0009-2474-8076
  • Edinilze Souza Coelho Oliveira Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-5910-4918
  • Andreia Montoia Salvador Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-8713-1120
  • Débora Nogueira Cavalcante Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0009-0001-1914-0834
  • Erickson Oliveira dos Santos Research Laboratory for Water Reuse, Samsung Research & Development Institute Brazil, Samsung Eletrônica da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-4569-905X
  • Pedro Luis Sosa Gonzales Research Laboratory for Water Reuse, Samsung Research & Development Institute Brazil, Samsung Eletrônica da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-8542-6320
  • Laura da Silva Cruz Universidade Federal de Alfenas, In vitro and in vivo Nutritional and Toxicological Analysis Laboratory, Alfenas, Minas Gerais, Brazil. https://orcid.org/0009-0006-4626-8741
  • Luciana Azevedo Universidade Federal de Alfenas, In vitro and in vivo Nutritional and Toxicological Analysis Laboratory, Alfenas, Minas Gerais, Brazil. https://orcid.org/0000-0002-0502-4090
  • Edgar Aparecido Sanches Universidade Federal do Amazonas, Materials Physics Department, Laboratory of Nanostructured Polymers, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-1446-723X
  • Pedro Henrique Campelo Universidade Federal de Viçosa, Department of Food Technology, Viçosa, Minas Gerais, Brazil. https://orcid.org/0000-0002-5137-0162
  • Valdely Ferreira Kinupp Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-3892-7288
  • Renilto Frota Corrêa Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0001-6236-2283
  • Jaqueline de Araujo Bezerra Instituto Federal de Educação, Ciência e Tecnologia do Amazonas, Centro de Estudos de Ciência e Tecnologia da Amazônia, Manaus, Amazonas, Brazil. https://orcid.org/0000-0002-9168-9864

DOI:

https://doi.org/10.5327/fst.525

Keywords:

Polygonaceae, Cipó-pau, Phenolic acids, Flavonoids, Cytotoxic activity

Abstract

The aim of the present study was to investigate the chemical profiles of the fruit extracts of Coccoloba marginata Benth and the cytotoxic activity of the ethanolic extract against two cell lines, HCT8 (human colon carcinoma) and A549 (lung adenocarcinoma). The ethanolic extract was found to contain gallic and protocatechuic acids, flavonoids derived from quercetin and myricetin, and anthocyanins. This extract inhibited the growth of cancer cells (GI50: 123.2 g GAE/mL for A549 and GI50: 44.15 g GAE/mL for HCT8, where GAE stands for Gallic Acid Equivalent) without cytotoxic effects on normal cells (GI50: 145.9 g GAE/mL for human umbilical vein endothelial cell). However, the selectivity index (< 1) indicated low specificity. Therefore, the results suggest that the phenolic compound-rich ethanolic extract exhibits promising antitumor effects. Nonetheless, further studies are needed to enhance its efficacy and selectivity, emphasizing the value of biodiversity for sustainable natural therapies.

 

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2025-10-06

How to Cite

Soares, J. V. S., Rocha, D. Q., Oliveira, E. S. C., Salvador, A. M., Cavalcante, D. N., Santos, E. O. dos, Gonzales, P. L. S., Cruz, L. da S., Azevedo, L., Sanches, E. A., Campelo, P. H., Kinupp, V. F., Corrêa, R. F., & Bezerra, J. de A. (2025). Coccoloba marginata Benth fruits: a rich source of bioactive compounds. Food Science and Technology, 45. https://doi.org/10.5327/fst.525

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Vol. 45 (2025)

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Original Articles